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Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

4 Jul 2023

Abstract excerpt

Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptive transfer. Recent progress in CAR-based therapies has led to outstanding clinical success in certain patients with leukemias and lymphomas and offered therapeutic benefits to those resistant to conventional...

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PMID: 37403182
DOI: 10.1186/s40364-023-00509-1

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