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Optimized conditions for gene transduction into primary immune cells using viral vectors

31 Jul 2023

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising modality for anti-cancer treatment. Its efficacy is quite remarkable in hematological tumors. Owing to their excellent clinical results, gene- modified cell therapies, including T cells, natural killer (NK) cells, and macrophages, are being actively studied in both academia and industry. However, the protocol to make CAR immune cells is too...

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PMID: 37524755
DOI: 10.1038/s41598-023-39597-2

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