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Article

The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis.

Journal of virology - 1 Jun 2011

Iglesias Nestor G, Filomatori Claudia V, Gamarnik Andrea V

Abstract excerpt

The mechanism by which viral RNA-dependent RNA polymerases (RdRp) specifically amplify viral genomes is still unclear. In the case of flaviviruses, a model has been proposed that involves the recognition of an RNA element present at the viral 5' untranslated region, stem-loop A (SLA), that serves as a promoter for NS5 polymerase binding and activity. Here, we investigated requirements for specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21471248
DOI: 10.1128/JVI.02343-10
PMCID: PMC3126321

Genes

SLA

Provenance

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The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis.PMID 21471248Read ↗

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