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Structural and functional characterization of the SLA′ structure at the 3′ terminus of the Zika virus negative-strand intermediate

8 May 2025

Abstract excerpt

Flavivirus infections, including those of Dengue virus (DENV) and Zika virus (ZIKV), result in a high disease burden globally, yet many aspects of their viral life cycle remain poorly understood. For example, while some features of the mechanism of negative-strand RNA synthesis are known, relatively little is known about the initiation of positive-strand RNA synthesis in the flavivirus life cycle. Viral RNA...

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PMID: 40341208
DOI: 10.1261/rna.080342.124

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