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Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping

13 Aug 2015

Abstract excerpt

Genome replication in flavivirus requires (-) strand RNA synthesis, (+) strand RNA synthesis, and 51-RNA capping and methylation. To carry out viral genome replication, flavivirus assembles a replication complex, consisting of both viral and host proteins, on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. Two major components of the replication complex are the viral non-structural (NS) proteins...

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PMID: 26287232
DOI: 10.3390/v7082837

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