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Article

Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

13 Nov 2008

Abstract excerpt

The 5' untranslated region (5'UTR) of the dengue virus (DENV) genome contains two defined elements essential for viral replication. At the 5' end, a large stem-loop (SLA) structure functions as the promoter for viral polymerase activity. Next to the SLA, there is a short stem-loop that contains a cyclization sequence known as the 5' upstream AUG region (5'UAR). Here, we analyzed the secondary structure of the SLA...

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Identifiers

PMID: 19004935
DOI: 10.1128/jvi.01647-08

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