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The Role of the Stem-Loop A RNA Promoter in Flavivirus Replication

9 Jun 2021

Abstract excerpt

An essential challenge in the lifecycle of RNA viruses is identifying and replicating the viral genome amongst all the RNAs present in the host cell cytoplasm. Yet, how the viral polymerase selectively recognizes and copies the viral RNA genome is poorly understood. In flaviviruses, the 5'-end of the viral RNA genome contains a 70 nucleotide-long stem-loop, called stem-loop A (SLA), which functions as a promoter...

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PMID: 34207869
DOI: 10.3390/v13061107

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