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Article

The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis.

Immunology - 1 Oct 2015

Di Mitri Diletta, Sambucci Manolo, Loiarro Maria, De Bardi Marco, Volpe Elisabetta, Cencioni Maria Teresa, Gasperini Claudio, Centonze Diego, Sette Claudio, Akbar Arne N, Borsellino Giovanna, Battistini Luca

Abstract excerpt

The p38 mitogen-activated protein kinase cascade is required for the induction of a T helper type 17 (Th17) -mediated autoimmune response, which underlies the development and progression of several autoimmune diseases, such as experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis (MS). However, the contribution of p38 phosphorylation to human Th cell differentiation has not been...

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Identifiers

PMID: 26095162
DOI: 10.1111/imm.12497
PMCID: PMC4582966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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