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Article

Serial profiling of cell-free DNA and nucleosome histone modifications in cell cultures.

Scientific reports - 4 May 2021

Ungerer Vida, Bronkhorst Abel J, Van den Ackerveken Priscilla, Herzog Marielle, Holdenrieder Stefan

Abstract excerpt

Recent advances in basic research have unveiled several strategies for improving the sensitivity and specificity of cell-free DNA (cfDNA) based assays, which is a prerequisite for broadening its clinical use. Included among these strategies is leveraging knowledge of both the biogenesis and physico-chemical properties of cfDNA towards the identification of better disease-defining features and optimization of...

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Identifiers

PMID: 33947882
DOI: 10.1038/s41598-021-88866-5
PMCID: PMC8096822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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