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Article

A new method for exploring gene-gene and gene-environment interactions in GWAS with tree ensemble methods and SHAP values.

BMC bioinformatics - 4 May 2021

Johnsen Pål V, Riemer-Sørensen Signe, DeWan Andrew Thomas, Cahill Megan E, Langaas Mette

Abstract excerpt

BACKGROUND: The identification of gene-gene and gene-environment interactions in genome-wide association studies is challenging due to the unknown nature of the interactions and the overwhelmingly large number of possible combinations. Parametric regression models are suitable to look for prespecified interactions. Nonparametric models such as tree ensemble models, with the ability to detect any unspecified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33947323
DOI: 10.1186/s12859-021-04041-7
PMCID: PMC8097909

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