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Article

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.

eLife - 4 May 2021

Morcom Laura, Edwards Timothy J, Rider Eric, Jones-Davis Dorothy, Lim Jonathan Wc, Chen Kok-Siong, Dean Ryan J, Bunt Jens, Ye Yunan, Gobius Ilan, Suárez Rodrigo, Mandelstam Simone, Sherr Elliott H, Richards Linda J

Abstract excerpt

Corpus callosum dysgenesis (CCD) is a congenital disorder that incorporates either partial or complete absence of the largest cerebral commissure. Remodelling of the interhemispheric fissure (IHF) provides a substrate for callosal axons to cross between hemispheres, and its failure is the main cause of complete CCD. However, it is unclear whether defects in this process could give rise to the heterogeneity of...

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Identifiers

PMID: 33945466
DOI: 10.7554/eLife.61618
PMCID: PMC8137145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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