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Article

DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.

eLife - 19 Apr 2021

Morcom Laura, Gobius Ilan, Marsh Ashley Pl, Suárez Rodrigo, Lim Jonathan Wc, Bridges Caitlin, Ye Yunan, Fenlon Laura R, Zagar Yvrick, Douglass Amelia M, Donahoo Amber-Lee S, Fothergill Thomas, Shaikh Samreen, Kozulin Peter, Edwards Timothy J, Cooper Helen M, Sherr Elliott H, Chédotal Alain, Leventer Richard J, Lockhart Paul J, Richards Linda J

Abstract excerpt

The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved function in...

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Identifiers

PMID: 33871356
DOI: 10.7554/eLife.61769
PMCID: PMC8116049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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