Article
Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum.
Cell reports - 11 Oct 2016
Gobius Ilan, Morcom Laura, Suárez Rodrigo, Bunt Jens, Bukshpun Polina, Reardon William, Dobyns William B, Rubenstein John L R, Barkovich A James, Sherr Elliott H, Richards Linda J
Abstract excerpt
The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening...
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