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Article

Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson's Disease Patient Monocytes and Inversely Correlates with Motor Severity.

Journal of Parkinson's disease - 1 Jan 2021

Hughes Laura P, Pereira Marilia M M, Hammond Deborah A, Kwok John B, Halliday Glenda M, Lewis Simon J G, Dzamko Nicolas

Abstract excerpt

BACKGROUND: Reduced activity of lysosomal glucocerebrosidase is found in brain tissue from Parkinson's disease patients. Glucocerebrosidase is also highly expressed in peripheral blood monocytes where its activity is decreased in Parkinson's disease patients, even in the absence of GBA mutation. OBJECTIVE: To measure glucocerebrosidase activity in cryopreserved peripheral blood monocytes from 30 Parkinson's...

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Identifiers

PMID: 33935104
DOI: 10.3233/JPD-202508
PMCID: PMC8461681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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