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Article

DNA replication fidelity: kinetics and thermodynamics.

Mutation research - 1 Jan 2000

Goodman M F

Abstract excerpt

Mechanisms that control the fidelity of DNA replication are discussed. Data are reviewed for 3 steps in a fidelity pathway: nucleotide insertion, exonucleolytic proofreading, and extension from matched and mismatched 3'-primer termini. Fidelity mechanisms that involve predominantly Km discrimination, Vmax discrimination, or a combination of the two are analyzed in the context of a simple model for fidelity. Each...

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Identifiers

PMID: 3393157
DOI: 10.1016/0027-5107(88)90067-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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