Article
DNA polymerase fidelity and the polymerase chain reaction.
PCR methods and applications - 1 Aug 1991
Eckert K A, Kunkel T A
Abstract excerpt
High-fidelity DNA synthesis conditions are those that exploit the inherent ability of polymerases to discriminate against errors. This review has described several experimental approaches for controlling the fidelity of enzymatic DNA amplification. One of the most important parameters to consider...
Topics
- DNA
- DNA Damage
- DNA-Directed DNA Polymerase
- Gene Amplification
- Humans
- Mutation
- Polymerase Chain Reaction
- Taq Polymerase