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Article

Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy

26 Oct 2015

Abstract excerpt

The term 'inhibitory checkpoint' refers to the broad spectrum of co-receptors expressed by T cells that negatively regulate T cell activation thus playing a crucial role in maintaining peripheral self-tolerance. Co-inhibitory receptor ligands are highly expressed by a variety of malignancies allowing evasion of anti-tumour immunity. Recent studies demonstrate that manipulation of these co-inhibitory pathways can...

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PMID: 26578451
DOI: 10.1016/j.molonc.2015.10.008

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