Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes Per1 and Per2.

Abstract excerpt

In mammals, numerous physiological and behavioural functions are controlled by an endogenous circadian clock located in the suprachiasmatic nuclei (SCN). Within the SCN neurons, clock genes such as Per1 and Per2 interact in a molecular clockwork regulating the expression of hundreds of output genes. Through the timed release of humoral and neuronal signals, the rhythmicity of numerous biological processes,...

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