Article
The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene.
Neurourology and urodynamics - 1 Nov 2018
Ihara Tatsuya, Mitsui Takahiko, Nakamura Yuki, Kanda Mie, Tsuchiya Sachiko, Kira Satoru, Nakagomi Hiroshi, Sawada Norifumi, Kamiyama Manabu, Shigetomi Eiji, Shinozaki Youichi, Yoshiyama Mitsuharu, Nakao Atsuhito, Takeda Masayuki, Koizumi Schuichi
Abstract excerpt
AIMS: The sensation of bladder fullness (SBF) is triggered by the release of ATP. Therefore, the aim of this study was to investigate whether time-dependent changes in the levels of stretch-released ATP in mouse primary-cultured urothelial cells (MPCUCs) is regulated by circadian rhythm via clock genes. METHODS: MPCUCs were derived from wild-type and Clock mutant mice (ClockΔ19/Δ19 ), presenting a nocturia...
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