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Article

Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.

Hepatology (Baltimore, Md.) - 1 Oct 2021

Chen Lixian, Wu Nan, Kennedy Lindsey, Francis Heather, Ceci Ludovica, Zhou Tianhao, Samala Niharika, Kyritsi Konstantina, Wu Chaodong, Sybenga Amelia, Ekser Burcin, Dar Wasim, Atkins Constance, Meadows Vik, Glaser Shannon, Alpini Gianfranco

Abstract excerpt

BACKGROUND AND AIMS: Human NAFLD is characterized at early stages by hepatic steatosis, which may progress to NASH when the liver displays microvesicular steatosis, lobular inflammation, and pericellular fibrosis. The secretin (SCT)/secretin receptor (SCTR) axis promotes biliary senescence and liver fibrosis in cholestatic models through down-regulation of miR-125b signaling. We aim to evaluate the effect of...

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Identifiers

PMID: 33928675
DOI: 10.1002/hep.31871
PMCID: PMC8782246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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