Article
p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling.
Hepatology (Baltimore, Md.) - 1 Jul 2023
Kundu Debjyoti, Kennedy Lindsey, Zhou Tianhao, Ekser Burcin, Meadows Vik, Sybenga Amelia, Kyritsi Konstantina, Chen Lixian, Ceci Ludovica, Wu Nan, Wu Chaodong, Glaser Shannon, Carpino Guido, Onori Paolo, Gaudio Eugenio, Alpini Gianfranco, Francis Heather
Abstract excerpt
BACKGROUND AND AIMS: NAFLD is characterized by steatosis, hepatic inflammation, and fibrosis, which can develop into NASH. Patients with NAFLD/NASH have increased ductular reaction (DR) and biliary senescence. High fat/high cholesterol diet feeding increases biliary senescence, DR, and biliary insulin-like growth factor-1 (IGF-1) expression in mice. p16/IGF-1 converges with fork-head box transcription factor O1...
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