Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti-PD-1 Therapy.

doi:10.1158/1078-0432.CCR-22-0041

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Article

Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti-PD-1 Therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 13 May 2022

Chida Keigo, Kawazoe Akihito, Suzuki Toshihiro, Kawazu Masahito, Ueno Toshihide, Takenouchi Kazumasa, Nakamura Yoshiaki, Kuboki Yasutoshi, Kotani Daisuke, Kojima Takashi, Bando Hideaki, Mishima Saori, Kuwata Takeshi, Sakamoto Naoya, Watanabe Jun, Mano Hiroyuki, Ikeda Masafumi, Shitara Kohei, Endo Itaru, Nakatsura Tetsuya, Yoshino Takayuki

Abstract excerpt

PURPOSE: Transcriptomic profiling was performed for microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal tumors to determine the predictors of response to PD-1 blockade. EXPERIMENTAL DESIGN: Thirty-six patients with MSI-H/dMMR gastrointestinal tumors, including gastric cancer, colorectal cancer, cholangiocarcinoma, small intestine cancer, and pancreatic cancer, being treated...

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Identifiers

PMID: 35254400
DOI: 10.1158/1078-0432.CCR-22-0041
PMCID: PMC9365358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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