Article
Five-year microevolution of a multidrug-resistant Mycobacterium tuberculosis strain within a patient with inadequate compliance to treatment.
BMC infectious diseases - 29 Apr 2021
Fernandez Do Porto Darío A, Monteserin Johana, Campos Josefina, Sosa Ezequiel J, Matteo Mario, Serral Federico, Yokobori Noemí, Benevento Andrés Fernández, Poklepovich Tomás, Pardo Agustín, Wainmayer Ingrid, Simboli Norberto, Castello Florencia, Paul Roxana, Martí Marcelo, López Beatriz, Turjanski Adrián, Ritacco Viviana
Abstract excerpt
BACKGROUND: Whole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought. Compartmentalized infections, exogenous reinfections, and microevolution are manifestations of this clonal complexity. The analysis of the mechanisms causing the microevolution -the genetic variability of M. tuberculosis at short time scales- of a parental strain...
Topics
- Adult
- Antitubercular Agents
- Argentina
- Drug Resistance, Multiple, Bacterial
- Female
- Humans
- Isoniazid
- Medication Adherence
- Microbial Sensitivity Tests