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Dynamic and complex Mycobacterium tuberculosis microevolution unrevealed by standard genotyping.

Tuberculosis (Edinburgh, Scotland) - 1 May 2012

Pérez-Lago Laura, Herranz Marta, Bouza Emilio, García de Viedma Darío

Abstract excerpt

We performed an in-depth analysis of a large Mycobacterium tuberculosis cluster involving nine isolates with identical or highly similar RFLP types. The strain involved in this transmission cluster microevolved and accumulated up to five differential IS6110 transposition events, several of them not revealed by standard genotyping approaches. Some of these events probably generated extended deletions. In two cases...

Topics

Bacterial Typing Techniques
Cluster Analysis
Evolution, Molecular
Genotype
Humans
Mycobacterium tuberculosis
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Tuberculosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22342248
DOI: 10.1016/j.tube.2012.01.003

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