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Article

Dynamic and complex Mycobacterium tuberculosis microevolution unrevealed by standard genotyping.

Tuberculosis (Edinburgh, Scotland) - 1 May 2012

Pérez-Lago Laura, Herranz Marta, Bouza Emilio, García de Viedma Darío

Abstract excerpt

We performed an in-depth analysis of a large Mycobacterium tuberculosis cluster involving nine isolates with identical or highly similar RFLP types. The strain involved in this transmission cluster microevolved and accumulated up to five differential IS6110 transposition events, several of them not revealed by standard genotyping approaches. Some of these events probably generated extended deletions. In two cases...

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PMID: 22342248
DOI: 10.1016/j.tube.2012.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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