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Article

Characterization of microevolution events in Mycobacterium tuberculosis strains involved in recent transmission clusters.

Journal of clinical microbiology - 1 Nov 2011

Pérez-Lago Laura, Herranz Marta, Lirola Miguel Martínez, Bouza Emilio, García de Viedma Darío

Abstract excerpt

Under certain circumstances, it is possible to identify clonal variants of Mycobacterium tuberculosis infecting a single patient, probably as a result of subtle genetic rearrangements in part of the bacillary population. We systematically searched for these microevolution events in a different context, namely, recent transmission chains. We studied the clustered cases identified using a population-based universal...

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Identifiers

PMID: 21940467
DOI: 10.1128/JCM.01285-11
PMCID: PMC3209131

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