Article
Association of HCV mutated proteins and host SNPs in the development of hepatocellular carcinoma.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2018
Suhail Mohd, Sohrab Sayed Sartaj, Qureshi Abid, Tarique Mohd, Abdel-Hafiz Hany, Al-Ghamdi Khalid, Qadri Ishtiaq
Abstract excerpt
Hepatitis C virus plays a significant role in the development of hepatocellular carcinoma (HCC) globally. The pathogenic mechanisms of hepatocellular carcinoma with HCV infection are generally linked with inflammation, cytokines, fibrosis, cellular signaling pathways, and liver cell proliferation modulating pathways. HCV encoded proteins (Core, NS3, NS4, NS5A) interact with a broad range of hepatocytes derived...
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