Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity.

The Biochemical journal - 1 Jan 2015

Chaudhary Fauzia, Lucito Robert, Tonks Nicholas K

Abstract excerpt

MIM (Missing-in-Metastasis), also known as MTSS1 (metastasis suppressor 1), is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared with non-metastatic counterparts. MIM regulates cytoskeletal dynamics and actin polymerization, and has been implicated in the control of cell motility and invasion. MIM has also been shown to bind to a receptor PTP (protein tyrosine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Epithelial Cells
Share to Mammary Glands, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Neoplasm Invasiveness

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to src-Family Kinases

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 25287652
DOI: 10.1042/BJ20140573
PMCID: PMC4312213

Genes

SRC
MTSS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity.PMID 25287652Read ↗

Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.Semantic proximity Read ↗

SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsivenessSemantic proximity Read ↗

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinantSemantic proximity Read ↗

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targetsSemantic proximity Read ↗

Perturbation of BRMS1 interactome reveals pathways that impact cell migrationSemantic proximity Read ↗

MET exon 14 skipping mutation drives cancer progression and recurrence via activation of SMAD2 signalling.Semantic proximity Read ↗

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.Semantic proximity Read ↗

SMYD3 promotes the epithelial–mesenchymal transition in breast cancerSemantic proximity Read ↗

ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule DynamicsSemantic proximity Read ↗

Metastatic function of METTL18 in breast cancer via actin methylation and SrcSemantic proximity Read ↗

Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical ApplicationSemantic proximity Read ↗

PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.