Article
Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype.
PloS one - 1 Jan 2014
Lopes Rafael L, Borges Thiago J, Araújo Jessica F, Pinho Nathana G, Bergamin Letícia S, Battastini Ana Maria O, Muraro Stéfanie P, Souza Ana Paula D, Zanin Rafael F, Bonorino Cristina
Abstract excerpt
Macrophages are myeloid cells that play an essential role in inflammation and host defense, regulating immune responses and maintaining tissue homeostasis. Depending on the microenvironment, macrophages can polarize to two distinct phenotypes. The M1 phenotype is activated by IFN-γ and bacterial products, and displays an inflammatory profile, while M2 macrophages are activated by IL-4 and tend to be...
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