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Article

COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jan 2022

Leung Wayne F, Chorlton Samuel, Tyson John, Al-Rawahi Ghada N, Jassem Agatha N, Prystajecky Natalie, Masud Shazia, Deans Gregory D, Chapman Michael G, Mirzanejad Yazdan, Murray Melanie C M, Wong Patrick H P

Abstract excerpt

This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

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Identifiers

PMID: 34757008
DOI: 10.1016/j.ijid.2021.10.045
PMCID: PMC8553657

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