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Article

Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.

European journal of pain (London, England) - 1 Feb 2010

Kohli Utkarsh, Muszkat Mordechai, Sofowora Gbenga G, Harris Paul A, Friedman Eitan A, Dupont William D, Scheinin Mika, Wood Alastair J J, Stein C Michael, Kurnik Daniel

Abstract excerpt

BACKGROUND: The mechanisms underlying interindividual variability in pain perception and cognitive responses are undefined but highly heritable. alpha(2C)- and alpha(2A)-adrenergic receptors regulate noradrenergic activity and are important mediators of pain perception and analgesia. We hypothesized that common genetic variants in these genes, particularly the ADRA2C 322-325 deletion variant, affect pain...

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Identifiers

PMID: 19423370
DOI: 10.1016/j.ejpain.2009.04.003
PMCID: PMC2815116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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