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Article

The Fertility Effects of the C677T Mutation in the Methylenetetrahydrofolate Reductase Gene: A Cross-Site Systematic Review and Meta-Analysis.

American journal of human biology : the official journal of the Human Biology Council - 1 Aug 2025

MacLean Caroline A, Dimanlig Miguel, Godfrey David, Madrigal Lorena

Abstract excerpt

INTRODUCTION: In this research, we seek to understand the evolutionary forces which have resulted in the distribution of the MTHFR C677T single nucleotide polymorphism, which is associated with fertility-related, cardiovascular, cancerous, and neurological morbidities. Due to the negative effects of the gene, it is likely frequent due to genetic drift or natural selection. METHODS: Using secondary data gathered...

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Identifiers

PMID: 40785353
DOI: 10.1002/ajhb.70119

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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The Fertility Effects of the C677T Mutation in the Methylenetetrahydrofolate Reductase Gene: A Cross-Site Systematic Review and Meta-Analysis.PMID 40785353Read ↗

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