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Impact of 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase on IVF outcome: is screening necessary for all infertile women?

Genetic testing and molecular biomarkers - 1 Sept 2012

Marci Roberto, Lisi Franco, Soave Ilaria, Lo Monte Giuseppe, Patella Alfredo, Caserta Donatella, Moscarini Massimo

Abstract excerpt

AIM: Polymorphisms of genes connected to folate metabolism may alter the beneficial effect of folic acid on the methyl group cycle. The most common variation is the 677C>T polymorphism of the gene of the 5,10-methylentetrahydrofolate reductase (MTHFR). The aim of this study is to investigate of what influence, if any, does MTHFR 677C>T mutation have on female fertility and on the in vitro fertilization (IVF)...

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Source

Identifiers

PMID: 22856671
DOI: 10.1089/gtmb.2012.0087

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Impact of 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase on IVF outcome: is screening necessary for all infertile women?PMID 22856671Read ↗

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