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Article

DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction.

Biomolecules - 17 May 2022

Vaughn Lauren S, Frederick Kenneth, Burnett Samuel B, Sharma Nutan, Bragg D Cristopher, Camargos Sarah, Cardoso Francisco, Patel Rekha C

Abstract excerpt

DYT-PRKRA (dystonia 16 or DYT-PRKRA) is caused by mutations in the PRKRA gene that encodes PACT, the protein activator of interferon (IFN)-induced double-stranded (ds) RNA-activated protein kinase (PKR). PACT participates in several cellular pathways, of which its role as a PKR activator protein during integrated stress response (ISR) is the best characterized. Previously, we have established that the DYT-PRKRA...

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Identifiers

PMID: 35625640
DOI: 10.3390/biom12050713
PMCID: PMC9138762

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