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Article

Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitro.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2015

Jiang Yi-Zhou, Manduchi Elisabetta, Jiménez Juan M, Davies Peter F

Abstract excerpt

Arterial endothelial phenotype is regulated by local hemodynamic forces that are linked to regional susceptibility to atherogenesis. A complex hierarchy of transcriptional, translational, and post-translational mechanisms is greatly influenced by the characteristics of local arterial shear stress environments. We discuss the emerging role of localized disturbed blood flow on epigenetic mechanisms of endothelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25838424
DOI: 10.1161/ATVBAHA.115.303427
PMCID: PMC4441576

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