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Article

Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways.

International journal of cancer - 1 Jan 2025

Pires Carolina, Marques Inês J, Saramago Ana, Moura Margarida M, Pojo Marta, Cabrera Rafael, Santos Catarina, Rosário Francisco, Lousa Diana, Vicente João B, Bandeiras Tiago M, Teixeira Manuel R, Leite Valeriano, Cavaco Branca M

Abstract excerpt

The genetic basis of nonsyndromic familial nonmedullary thyroid carcinoma (FNMTC) is still poorly understood, as the susceptibility genes identified so far only account for a small percentage of the genetic burden. Recently, germline mutations in DNA repair-related genes have been reported in cases with thyroid cancer. In order to clarify the genetic basis of FNMTC, 94 genes involved in hereditary cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39251783
DOI: 10.1002/ijc.35159

Genes

DICER1
ATM
BRCA2
BUB1B
CHEK2
ERCC2
ERCC4
FANCA
FANCD2
FANCF
FLCN
PALB2
PTCH1
RHBDF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways.PMID 39251783Read ↗

Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid CancerSemantic proximity Read ↗

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Novel Susceptibility Genes Drive Familial Non-Medullary Thyroid Cancer in a Large Consanguineous Kindred.Semantic proximity Read ↗

CHEK2 germline variants identified in familial nonmedullary thyroid cancer lead to impaired protein structure and function.Semantic proximity Read ↗

Clinically Relevant Germline Variants in Children With Nonmedullary Thyroid Cancer.Semantic proximity Read ↗

Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer.Semantic proximity Read ↗

Familial non-medullary thyroid cancer: unraveling the genetic maze.Semantic proximity Read ↗

Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.Semantic proximity Read ↗

BROX haploinsufficiency in familial nonmedullary thyroid cancer.Semantic proximity Read ↗

Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art StudiesSemantic proximity Read ↗

Genetics of Familial Non-Medullary Thyroid Carcinoma (FNMTC)Semantic proximity Read ↗

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