Article
Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis.
Archives of endocrinology and metabolism - 1 Nov 2021
Peres Karina Colombera, Teodoro Larissa, Amaral Laís Helena Pereira, Teixeira Elisângela Souza, Barreto Icléia Siqueira, de Freitas Leandro Luiz Lopes, Maximo Valdemar, Assumpção Lígia V Montalli, Bufalo Natassia Elena, Ward Laura Sterian
Abstract excerpt
OBJECTIVE: Abnormalities involving the TGFB1 gene and its receptors are common in several types of cancer and often related to tumor progression. We investigated the role of single nucleotide polymorphisms (SNP) in the susceptibility to cancer, their impact on its features, as well as the role of mRNA expression of these genes in thyroid malignancy. METHODS: We genotyped TGFB1, TGFBR1, and TGFBR2 SNPs in 157...
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