Article
Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility.
European thyroid journal - 1 Jun 2025
Condello Vincenzo, Doerfler William R, Nikitski Alyaksandr V, Spagnolo Daniel M, Fornal Ian J, Schmidt Gavin M, Wald Abigail I, Nikiforova Marina N, Nikiforov Yuri E
Abstract excerpt
Introduction: Mutations of RAS genes are detected in a spectrum of follicular-patterned thyroid tumors. Preoperative prediction of invasive cancers based on the presence of RAS mutation alone is challenging because non-invasive and invasive tumors tend to have similar sonographic and cytologic features. The aim of this study was to perform clinicopathologic and molecular analyses of RAS-mutant tumors, identify...
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