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Article

Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma.

Respiratory research - 26 Apr 2021

Chen Ailu, Diaz-Soto Maria P, Sanmamed Miguel F, Adams Taylor, Schupp Jonas C, Gupta Amolika, Britto Clemente, Sauler Maor, Yan Xiting, Liu Qing, Nino Gustavo, Cruz Charles S Dela, Chupp Geoffrey L, Gomez Jose L

Abstract excerpt

BACKGROUND: Asthma has been associated with impaired interferon response. Multiple cell types have been implicated in such response impairment and may be responsible for asthma immunopathology. However, existing models to study the immune response in asthma are limited by bulk profiling of cells. Our objective was to Characterize a model of peripheral blood mononuclear cells (PBMCs) of patients with severe asthma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33902571
DOI: 10.1186/s12931-021-01709-9
PMCID: PMC8074196

Genes

CD4
JAK1
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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