Article
ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells.
Nature communications - 16 Mar 2015
Mele Federico, Basso Camilla, Leoni Cristina, Aschenbrenner Dominik, Becattini Simone, Latorre Daniela, Lanzavecchia Antonio, Sallusto Federica, Monticelli Silvia
Abstract excerpt
T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced in both human and mouse naive T cells differentiating into the TH17, but not TH1 or TH2 subset. In human memory TH17 cells, miR-181a regulates responses to...
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