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Article

CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia.

Neurobiology of aging - 1 Jul 2021

van der Ende Emma L, Morenas-Rodriguez Estrella, McMillan Corey, Grossman Murray, Irwin David, Sanchez-Valle Raquel, Graff Caroline, Vandenberghe Rik, Pijnenburg Yolande A L, Laforce Robert, Ber Isabelle Le, Lleo Alberto, Haass Christian, Suarez-Calvet Marc, van Swieten John C, Seelaar Harro

Abstract excerpt

Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation...

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Identifiers

PMID: 33896652
DOI: 10.1016/j.neurobiolaging.2021.02.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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