Article
Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon.
Genes & development - 1 Nov 1998
Dukan S, Nyström T
Abstract excerpt
Aging, or senescence, is the progressive deterioration of every bodily function over time. A fundamental question that applies to all life forms, including growth-arrested bacteria, is why growing older by necessity causes organisms to grow more fragile. In this work, we demonstrate that the leve...
Topics
- Alkaline Phosphatase
- Bacterial Proteins
- Cytoplasm
- DNA-Binding Proteins
- Disulfides
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Mutation
- Oxidation-Reduction
- Regulon
- Repressor Proteins
- Sigma Factor
- Superoxide Dismutase
- Transcription Factors