Genomic profile of advanced breast cancer in circulating tumour DNA.

doi:10.1038/s41467-021-22605-2

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Article

Genomic profile of advanced breast cancer in circulating tumour DNA.

Nature communications - 23 Apr 2021

Kingston Belinda, Cutts Rosalind J, Bye Hannah, Beaney Matthew, Walsh-Crestani Giselle, Hrebien Sarah, Swift Claire, Kilburn Lucy S, Kernaghan Sarah, Moretti Laura, Wilkinson Katie, Wardley Andrew M, Macpherson Iain R, Baird Richard D, Roylance Rebecca, Reis-Filho Jorge S, Hubank Michael, Faull Iris, Banks Kimberly C, Lanman Richard B, Garcia-Murillas Isaac, Bliss Judith M, Ring Alistair, Turner Nicholas C

Abstract excerpt

The genomics of advanced breast cancer (ABC) has been described through tumour tissue biopsy sequencing, although these approaches are limited by geographical and temporal heterogeneity. Here we use plasma circulating tumour DNA sequencing to interrogate the genomic profile of ABC in 800 patients in the plasmaMATCH trial. We demonstrate diverse subclonal resistance mutations, including enrichment of HER2...

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Identifiers

PMID: 33893289
DOI: 10.1038/s41467-021-22605-2
PMCID: PMC8065112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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