Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms.

doi:10.1158/0008-5472.CAN-17-2686

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Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms.

Cancer research - 15 Feb 2018

Paoletti Costanza, Cani Andi K, Larios Jose M, Hovelson Daniel H, Aung Kimberly, Darga Elizabeth P, Cannell Emily M, Baratta Paul J, Liu Chia-Jen, Chu David, Yazdani Maryam, Blevins Allen R, Sero Valeria, Tokudome Nahomi, Thomas Dafydd G, Gersch Christina, Schott Anne F, Wu Yi-Mi, Lonigro Robert, Robinson Dan R, Chinnaiyan Arul M, Bischoff Farideh Z, Johnson Michael D, Park Ben H, Hayes Daniel F, Rae James M, Tomlins Scott A

Abstract excerpt

Addressing drug resistance is a core challenge in cancer research, but the degree of heterogeneity in resistance mechanisms in cancer is unclear. In this study, we conducted next-generation sequencing (NGS) of circulating tumor cells (CTC) from patients with advanced cancer to assess mechanisms of resistance to targeted therapy and reveal opportunities for precision medicine. Comparison of the genomic landscapes...

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PMID: 29233927
DOI: 10.1158/0008-5472.CAN-17-2686
PMCID: PMC5815882

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ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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