Article
Novel recessive locus for body mass index in childhood asthma.
Thorax - 1 Dec 2021
Lee Sanghun, Lasky-Su Jessica, Won Sungho, Laurie Cecelia, Celedón Juan Carlos, Lange Christoph, Weiss Scott, Hecker Julian
Abstract excerpt
Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in FTO In two whole-genome sequencing (WGS) studies of children with asthma and their parents (892 Costa Rican trios and 286 North American trios), we...
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