Article
A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity.
American journal of human genetics - 6 Mar 2014
González Juan R, Cáceres Alejandro, Esko Tonu, Cuscó Ivon, Puig Marta, Esnaola Mikel, Reina Judith, Siroux Valerie, Bouzigon Emmanuelle, Nadif Rachel, Reinmaa Eva, Milani Lili, Bustamante Mariona, Jarvis Deborah, Antó Josep M, Sunyer Jordi, Demenais Florence, Kogevinas Manolis, Metspalu Andres, Cáceres Mario, Pérez-Jurado Luis A
Abstract excerpt
The prevalence of asthma and obesity is increasing worldwide, and obesity is a well-documented risk factor for asthma. The mechanisms underlying this association and parallel time trends remain largely unknown but genetic factors may be involved. Here, we report on a common ~0.45 Mb genomic inversion at 16p11.2 that can be accurately genotyped via SNP array data. We show that the inversion allele protects against...
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