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Article

Genetic predisposition to elevated BMI and adult asthma phenotypes in a Japanese population.

PloS one - 1 Jan 2026

Yatagai Yohei, Oshima Hisayuki, Abe Yu, Kitazawa Haruna, Masuko Hironori, Naito Takashi, Saito Takefumi, Hirota Tomomitsu, Tamari Mayumi, Noguchi Emiko, Sakamoto Tohru, Hizawa Nobuyuki

Abstract excerpt

Obesity is a well-established risk factor for asthma, with genetic factors influencing both conditions. This study investigates the impact of genetic predisposition to increased body mass index (BMI) on adult asthma phenotypes. We recruited 1532 non-asthmatic healthy individuals and 779 adult asthma patients to assess the relationship between BMI-related genetic risk scores (BMI-GRS) and asthma. Among the 85...

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Identifiers

PMID: 41610132
DOI: 10.1371/journal.pone.0340728
PMCID: PMC12854457

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