Article
PRKCA: a positional candidate gene for body mass index and asthma.
American journal of human genetics - 1 Jul 2009
Murphy Amy, Tantisira Kelan G, Soto-Quirós Manuel E, Avila Lydiana, Klanderman Barbara J, Lake Stephen, Weiss Scott T, Celedón Juan C
Abstract excerpt
Asthma incidence and prevalence are higher in obese individuals. A potential mechanistic basis for this relationship is pleiotropy. We hypothesized that significant linkage and candidate-gene association would be found for body mass index (BMI) in a population ascertained on asthma affection status. Linkage analysis for BMI was performed on 657 subjects in eight Costa Rican families enrolled in a study of asthma....
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