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Article

Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma

22 Nov 2020

Abstract excerpt

Background and Aims Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. Different epigenetic modifications occur in CCA and contribute to malignancy. Targeting epigenetic mechanisms may thus open therapeutic opportunities. However,...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 33222246
DOI: 10.1002/hep.31642

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