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Article

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.

Blood cancer journal - 18 Jul 2023

Tefferi Ayalew, Alkhateeb Hassan, Gangat Naseema

Abstract excerpt

Leukemic transformation in myeloproliferative neoplasms (MPN), also referred to as "blast-phase MPN", is the most feared disease complication, with incidence estimates of 1-4% for essential thrombocythemia, 3-7% for polycythemia vera, and 9-13% for primary myelofibrosis. Diagnosis of MPN-BP requires the presence of ≥20% circulating or bone marrow blasts; a lower level of excess blasts (10-19%) constitutes...

Topics

Humans
Blast Crisis
Retrospective Studies
Neoplasm Recurrence, Local
Myeloproliferative Disorders
Polycythemia Vera
Mutation
Chronic Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37460550
DOI: 10.1038/s41408-023-00878-8
PMCID: PMC10352315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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