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MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa.

Genetic testing and molecular biomarkers - 1 Apr 2021

Hayashi Tasuku, Shibata Tomoyuki, Nakamura Masakatsu, Sakurai Naoko, Takano Hikaru, Ota Masafumi, Nomura-Horita Tomoe, Hayashi Ranji, Shimasaki Takeo, Ostuka Toshimi, Tahara Tomomitsu, Arisawa Tomiyasu

Abstract excerpt

Objective: This study aimed to clarify the association of MAFK polymorphisms (rs4268033, rs3735656, and rs10226620) with the degree of gastric mucosal atrophy and CDKN2A CpG methylation status. Methods: A total of 491 subjects were enrolled in this study. Genotypes and methylation status were determined by polymerase chain reaction (PCR)-single-stranded conformation polymorphism and methylation-specific PCR...

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PMID: 33877894
DOI: 10.1089/gtmb.2020.0299

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